Estrogen for transgender

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Transgender women are women whose recorded sex at birth was male but whose gender identity is female. Transfeminine people represent a group that includes not just transgender women but also non-binary people who have a more feminine gender identity than the one that is expected for their recorded sex at birth. Many transgender people experience what is known as gender dysphoria —this is discomfort caused by people's bodies not matching their sense of identity.

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The use of estrogen therapy in transgender women appears to put them at increased risk for cardiac events, a review of the available scientific literature found. The analysis found a "definite" increase in venous thromboembolism VTE and "probable" increases in both the risk of myocardial infarction MI and stroke among transgender women those born biologically male but identifying as femaleaccording to Michael Irwig, MD, of George Washington University School of Medicine and Health Sciences in Washington. Among transgender men those born as female but identifying as malethere appeared to be no increase in stroke or VTE, while the risk of MI is still unknown, as reported in Reviews in Endocrine and Metabolic Disorders.

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In transgender men, or trans masculine people FTMthe most common medication used for transition is testosterone. Administration of testosterone via transdermal, intramuscular, subcutaneous, or oral routes lowers serum estradiol levels, raises serum testosterone levels, and results in the development of typical male secondary sex characteristics. Irreversible changes include: deepening of the voice, increase in facial and body hair growth, clitoral enlargement clitoromegalyand thickened facial bone structure.

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Purpose: Maintaining cross-sex hormone levels in the normal physiologic range for the desired gender is the cornerstone of transgender hormonal therapy, but there are limited data on how to achieve this. We investigated the effectiveness of oral estradiol therapy in achieving this goal. Methods: We analyzed data on all transgender females seen in our clinic since treated with oral estradiol.

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Many transgender men and women seek hormone therapy as part of the transition process. Exogenous testosterone is used in transgender men to induce virilization and suppress feminizing characteristics. In transgender women, exogenous estrogen is used to help feminize patients, and anti-androgens are used as adjuncts to help suppress masculinizing features.

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In transgender women who have had their testes removed as part of the gender-affirming process, a form of estrogen called estradiol strengthens connections between areas of the brain involved in fine motor skills, learning, emotions and sensory perception, according a study to be presented Monday at ENDOthe Endocrine Society's annual meeting in New Orleans, La. These findings reflect changes on the brain that might have implications, for instance, for treating hot flashes and other symptoms in transgender women, the researchers say. Without any sex hormones, transgender women have the same symptoms, such as hot flashes, that postmenopausal women have, she said.

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For full functionality of ResearchGate it is necessary to enable JavaScript. Here are the instructions how to enable JavaScript in your web browser. Reading: Transgender women on hormone therap

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Supporting a person's gender identity improves their psychological health, and gender-affirming hormones reduce gender dysphoria and benefit mental health. For transgender women, estrogen administration has clinically significant benefits. Previous reviews have reported conflicting literature on the thrombotic risk of estrogen therapy in transgender women and have highlighted the need for more high-quality research. CONTENT: To help address the gap in understanding thrombotic risk in transgender women receiving estrogen therapy, we performed a systematic literature review and metaanalysis.

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Corrected 4 July View correction. People assigned as males at birth who transition to female gender are transgender females.

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One of the most often cited reasons by medical providers for hesitation in providing hormone therapy to transgender individuals is the fear of harm. The review demonstrates that hormone therapy is relatively safe, at least as far as the modest literature out there can determine. Providers should be reassured that the harms that do exist are relatively rare and can often be avoided with conventional monitoring. The current literature suggests that transgender hormone therapy is safe for most situations and reasonable to monitor.

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